GSK-2656157 | 9466

GSK-2656157 is a potent, selective and ATP-competitive inhibitor of PERK (protein kinase R-like ER kinase) enzyme activity with an IC₅₀ of 0.9 nM; displays high selectivity for PERK against a panel of 300 kinases (IC₅₀>100 nM).

GSK-2656157 is a potent, selective and ATP-competitive inhibitor of PERK (protein kinase R-like ER kinase) enzyme activity with an IC₅₀ of 0.9 nM; displays high selectivity for PERK against a panel of 300 kinases (IC₅₀>100 nM).

9466 | GSK-2656157 DataSheet

Alternate Name/Synonyms: 1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyridin-2-yl)ethanone

Appearance: White solid

Formulation: N/A

CAS Number: 1337532-29-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₃H₂₁FN₆O

Molecular Weight: 416.45

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selctive PERK (protein kinase R-like ER kinase) inhibitor

MDL Number: N/A

PubChem CID: 53469059

SMILES: CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=C4C(=NC=N5)N)C

InChi: InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)

InChi Key: PRWSIEBRGXYXAJ-UHFFFAOYSA-N