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GSK-269962 hydrochloride | B2425
- SKU:
- 26-B2425-GEN
- Availability:
- Usually shipped in 5 working days
Description
GSK-269962 is a potent and selective Rho kinase (ROCK) inhibitor (IC₅₀ values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). It displays >30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC₅₀ = 35 nM) and lowers blood pressure in a rat model of hypertension.
GSK-269962 is a potent and selective Rho kinase (ROCK) inhibitor (IC₅₀ values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). It displays >30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC₅₀ = 35 nM) and lowers blood pressure in a rat model of hypertension.
B2425 | GSK-269962 hydrochloride DataSheet
Alternate Name/Synonyms: GSK26996B, GSK-269962A, N-[3-[[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]-benzamide hydrochloride, GSK269962
Appearance: Crystalline solid
Formulation:
CAS Number: 2095432-71-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₉H₃₁ClN₈O₅
Molecular Weight: 607.07
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >50 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent and selective Rho Kinase (ROCK) inhibitor
MDL Number:
PubChem CID: 57398146
SMILES: CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6.Cl
InChi: InChI=1S/C29H30N8O5.ClH/c1-2-37-24-17-25(31-18-23(24)33-28(37)26-27(30)35-42-34-26)41-22-5-3-4-20(16-22)32-29(38)19-6-8-21(9-7-19)40-15-12-36-10-13-39-14-11-36;/h3-9,16-18H,2,10-15H2,1H3,(H2,30,35)(H,32,38);1H
InChi Key: UYKVMFKKKLLDGL-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |