GSK-3368715 | B2745

GSK-3368715 is a potent, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). Displays anti-cancer activity.

GSK-3368715 is a potent, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). Displays anti-cancer activity.

B2745 | GSK-3368715 DataSheet

Alternate Name/Synonyms: EPZ019997,N1-((3-(4,4-Bis(ethoxymethyl)cyclohexyl)-1H-pyrazol-4-yl)methyl)-N1,N2-dimethylethane-1,2-diamine

Appearance: Crystalline solid

Formulation:

CAS Number: 1629013-22-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₃₈N₄O₂

Molecular Weight: 366.55

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >50 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: Type I Protein Arginine Methyltransferases (PRMTs) inhibitor

MDL Number:

PubChem CID: 90462880

SMILES: CCOCC1(CCC(CC1)C2=C(C=NN2)CN(C)CCNC)COCC

InChi: InChI=1S/C20H38N4O2/c1-5-25-15-20(16-26-6-2)9-7-17(8-10-20)19-18(13-22-23-19)14-24(4)12-11-21-3/h13,17,21H,5-12,14-16H2,1-4H3,(H,22,23)

InChi Key: SPEGERVLTUWZPA-UHFFFAOYSA-N