GSK-3484862 | B3326

GSK3484862 (GSKMI-714) is a selective, reversible, non-covalent DNMT1 (DNA Methyltransferase 1) inhibitor. Potently inhibits the methyltransferase activity of DNMT1, but not DNMT family members DNMT3A or DNMT3B.

GSK3484862 (GSKMI-714) is a selective, reversible, non-covalent DNMT1 (DNA Methyltransferase 1) inhibitor. Potently inhibits the methyltransferase activity of DNMT1, but not DNMT family members DNMT3A or DNMT3B.

B3326 | GSK-3484862 DataSheet

Alternate Name/Synonyms: (2R)-2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide GSKMI-714

Appearance: Solid

Formulation:

CAS Number: 2170136-65-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₉N₅OS

Molecular Weight: 365.45

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >20 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A non-covalent Dnmt1 inhibitor

MDL Number:

PubChem CID: 132233666

SMILES: CCC1=C(C(=NC(=C1C#N)SC(C2=CC=CC=C2)C(=O)N)N(C)C)C#N

InChi: InChI=1S/C19H19N5OS/c1-4-13-14(10-20)18(24(2)3)23-19(15(13)11-21)26-16(17(22)25)12-8-6-5-7-9-12/h5-9,16H,4H2,1-3H3,(H2,22,25)/t16-/m1/s1

InChi Key: KIEQQZZDWUNUQK-MRXNPFEDSA-N