GSK-3787 | 2400

GSK-3787 is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor delta (PPARδ) (plC₅₀ = 6.6). It covalently binds to Cys 249 in the PPARδ binding site.

GSK-3787 is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor delta (PPARδ) (plC₅₀ = 6.6).

2400 | GSK-3787 DataSheet

Alternate Name/Synonyms: 4-Chloro-N-(2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide

Appearance: White solid

Formulation: N/A

CAS Number: 188591-46-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₂ClF₃N₂O₃S

Molecular Weight: 392.78

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~30 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A potent PPARδ antagonist

MDL Number: MFCD00099612

PubChem CID: 2800647

SMILES: C1=CC(=CC=C1C(=O)NCCS(=O)(=O)C2=NC=C(C=C2)C(F)(F)F)Cl

InChi: InChI=1S/C15H12ClF3N2O3S/c16-12-4-1-10(2-5-12)14(22)20-7-8-25(23,24)13-6-3-11(9-21-13)15(17,18)19/h1-6,9H,7-8H2,(H,20,22)

InChi Key: JFUIMTGOQCQTPF-UHFFFAOYSA-N