GSK-3a Antibody [SBGSK3a2] (HRP) | 99-743

GSK-3a Antibody [SBGSK3a2] (HRP) | 99-743 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: N/A

Research Area: Cell Cycle, Neuroscience, Signal Transduction

Tested Application: Flow

Application: GSK-3a Antibody [SBGSK3a2] for use in western blotting assays.

Specificiy: GSK-3alpha

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [SBGSK3a2]

Isotype: IgG2a

Conjugate: HRP

Physical State: Liquid

Buffer: Supplied in a stock solution of 50% glycerol/50% PBS, pH 7.4; No preservative added

Concentration: Lot specific

Storage Condition: Store vial at 2-8˚C

Alternate Name: Glycogen synthase kinase-3

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3alpha and GSK-3beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility.