GSK-484 hydrochloride | B1035

GSK-484 is a potent and reversible inhibitor of PAD4 (Protein Arginine Deiminase 4) (IC₅₀ = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK-484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils.

GSK-484 is a potent and reversible inhibitor of PAD4 (Protein Arginine Deiminase 4) (IC₅₀ = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK-484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils.

B1035 | GSK-484 hydrochloride DataSheet

Alternate Name/Synonyms: ((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1652591-81-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₃₂ClN₅O₃

Molecular Weight: 510.03

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (~30 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent protein arginine deiminase 4 (PAD4) inhibitor

MDL Number: N/A

PubChem CID: 86340151

SMILES: CN1C2=C(C=C(C=C2OC)C(=O)N3CCC(C(C3)N)O)N=C1C4=CC5=CC=CC=C5N4CC6CC6.Cl

InChi: InChI=1S/C27H31N5O3.ClH/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(28)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16;/h3-6,11-13,16,19,23,33H,7-10,14-15,28H2,1-2H3;1H/t19-,23+;/m0./s1

InChi Key: MULKOGJHUZTANI-ADMBKAPUSA-N