GSK-5959 | B2343

GSK-5959 is a potent and selective BRPF1 (BR140 or Peregrin) bromodomain inhibitor (IC₅₀ = 80 nM). GSK-5959 displays >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains. BRPF1 (bromodomain and PHD finger containing protein 1) is involved in the epigenetic regulation of gene expression and have been implicated in human cancer.

GSK-5959 is a potent and selective BRPF1 (BR140 or Peregrin) bromodomain inhibitor (IC₅₀ = 80 nM). GSK-5959 displays >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains. BRPF1 (bromodomain and PHD finger containing protein 1) is involved in the epigenetic regulation of gene expression and have been implicated in human cancer.

B2343 | GSK-5959 DataSheet

Alternate Name/Synonyms: N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide,GSK5959

Appearance: Pale yellow solid

Formulation:

CAS Number: 901245-65-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₂H₂₆N₄O₃

Molecular Weight: 394.47

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: ~4 mg/ml (DMSO)

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective BRPF1 bromodomain inhibitor

MDL Number:

PubChem CID: 15990224

SMILES: CN1C2=CC(=C(C=C2N(C1=O)C)N3CCCCC3)NC(=O)C4=CC=CC=C4OC

InChi: InChI=1S/C22H26N4O3/c1-24-18-13-16(23-21(27)15-9-5-6-10-20(15)29-3)17(26-11-7-4-8-12-26)14-19(18)25(2)22(24)28/h5-6,9-10,13-14H,4,7-8,11-12H2,1-3H3,(H,23,27)

InChi Key: LTUGYAOMCKNTGG-UHFFFAOYSA-N