Description
GSK-5959 is a potent and selective BRPF1 (BR140 or Peregrin) bromodomain inhibitor (IC₅₀ = 80 nM). GSK-5959 displays >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains. BRPF1 (bromodomain and PHD finger containing protein 1) is involved in the epigenetic regulation of gene expression and have been implicated in human cancer.
GSK-5959 is a potent and selective BRPF1 (BR140 or Peregrin) bromodomain inhibitor (IC₅₀ = 80 nM). GSK-5959 displays >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains. BRPF1 (bromodomain and PHD finger containing protein 1) is involved in the epigenetic regulation of gene expression and have been implicated in human cancer.
Alternate Name/Synonyms: N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide,GSK5959
Appearance: Pale yellow solid
Formulation:
CAS Number: 901245-65-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₂H₂₆N₄O₃
Molecular Weight: 394.47
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: ~4 mg/ml (DMSO)
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent and selective BRPF1 bromodomain inhibitor
MDL Number:
PubChem CID: 15990224
SMILES: CN1C2=CC(=C(C=C2N(C1=O)C)N3CCCCC3)NC(=O)C4=CC=CC=C4OC
InChi: InChI=1S/C22H26N4O3/c1-24-18-13-16(23-21(27)15-9-5-6-10-20(15)29-3)17(26-11-7-4-8-12-26)14-19(18)25(2)22(24)28/h5-6,9-10,13-14H,4,7-8,11-12H2,1-3H3,(H,23,27)
InChi Key: LTUGYAOMCKNTGG-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |