GSK-626616 | B2452

GSK-626616 is a potent and selective DYRK inhibitor (IC₅₀ = 0.7 nM); inhibits other members of the DYRK family, e.g., DYRK1A and DYRK2, with similar potency. Displays ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened.

GSK-626616 is a potent and selective DYRK inhibitor (IC₅₀ = 0.7 nM); inhibits other members of the DYRK family, e.g., DYRK1A and DYRK2, with similar potency. Displays ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened.

B2452 | GSK-626616 DataSheet

Alternate Name/Synonyms: (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone

Appearance: Pale orange solid

Formulation:

CAS Number: 1025821-33-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₀Cl₂N₄OS

Molecular Weight: 401.27

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >35 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective DYRK inhibitor

MDL Number: MFCD31689261

PubChem CID: 135416229

SMILES: C1=CC(=C(C(=C1)Cl)N=C2NC(=O)C(=CC3=CC4=NC=CN=C4C=C3)S2)Cl

InChi: InChI=1S/C18H10Cl2N4OS/c19-11-2-1-3-12(20)16(11)23-18-24-17(25)15(26-18)9-10-4-5-13-14(8-10)22-7-6-21-13/h1-9H,(H,23,24,25)/b15-9-

InChi Key: RJPNRXFBYZVRIB-DHDCSXOGSA-N