GSK-650394 | B2093

GSK-650394 is a potent inhibitor of serum- and glucocorticoid-regulated kinase (IC₅₀s = 62 and 103 nM for SGK1 and SGK2, respectively). It demonstrates greater than 30-fold selectivity for SGK1 over Akt and other related kinases. GSK-650394 can inhibit the androgen-stimulated growth of human prostate carcinoma LNCaP cells with an IC₅₀ value of ~ 1 μM.

GSK-650394 is a potent inhibitor of serum- and glucocorticoid-regulated kinase (IC₅₀s = 62 and 103 nM for SGK1 and SGK2, respectively). It demonstrates greater than 30-fold selectivity for SGK1 over Akt and other related kinases. GSK-650394 can inhibit the androgen-stimulated growth of human prostate carcinoma LNCaP cells with an IC₅₀ value of ~ 1 μM.

B2093 | GSK-650394 DataSheet

Alternate Name/Synonyms: 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 890842-28-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₂N₂O₂

Molecular Weight: 382.45

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of serum- and glucocorticoid-regulated kinase

MDL Number: N/A

PubChem CID: 25022668

SMILES: C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=NC=C(C=C34)C5=CC=CC=C5)C(=O)O

InChi: InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)

InChi Key: WVSBGSNVCDAMCF-UHFFFAOYSA-N