GSK2256098 | B1224

GSK2256098 (GTPL7939) is a focal adhesion kinase-1 (FAK-1) inhibitor with potential antineoplastic and antiangiogenic activity. FAK is normally activated by integrin binding to extra cellular matrix and might be upregulated and activated in various tumor types. This inhibition of FAK-1 kinase prevents downstream signal transduction pathways mediated by integrin activation including ERK, JNK/MAPK and PI3/Akt thus inhibiting tumor cell migration, proliferation and survival.

GSK2256098 (GTPL7939) is a focal adhesion kinase-1 (FAK-1) inhibitor with potential antineoplastic and antiangiogenic activity. FAK is normally activated by integrin binding to extra cellular matrix and might be upregulated and activated in various tumor types. This inhibition of FAK-1 kinase prevents downstream signal transduction pathways mediated by integrin activation including ERK, JNK/MAPK and PI3/Akt thus inhibiting tumor cell migration, proliferation and survival.

B1224 | GSK2256098 DataSheet

Alternate Name/Synonyms: 2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1224887-10-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₃ClN₆O₂

Molecular Weight: 414.89

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A focal adhesion kinase-1 (FAK-1) inhibitor with potential antineoplastic and antiangiogenic activity.

MDL Number: N/A

PubChem CID: 46214930

SMILES: CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C

InChi: InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)

InChi Key: BVAHPPKGOOJSPU-UHFFFAOYSA-N