Description
GSK2256098 (GTPL7939) is a focal adhesion kinase-1 (FAK-1) inhibitor with potential antineoplastic and antiangiogenic activity. FAK is normally activated by integrin binding to extra cellular matrix and might be upregulated and activated in various tumor types. This inhibition of FAK-1 kinase prevents downstream signal transduction pathways mediated by integrin activation including ERK, JNK/MAPK and PI3/Akt thus inhibiting tumor cell migration, proliferation and survival.
GSK2256098 (GTPL7939) is a focal adhesion kinase-1 (FAK-1) inhibitor with potential antineoplastic and antiangiogenic activity. FAK is normally activated by integrin binding to extra cellular matrix and might be upregulated and activated in various tumor types. This inhibition of FAK-1 kinase prevents downstream signal transduction pathways mediated by integrin activation including ERK, JNK/MAPK and PI3/Akt thus inhibiting tumor cell migration, proliferation and survival.
Alternate Name/Synonyms: 2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1224887-10-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₂₃ClN₆O₂
Molecular Weight: 414.89
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A focal adhesion kinase-1 (FAK-1) inhibitor with potential antineoplastic and antiangiogenic activity.
MDL Number: N/A
PubChem CID: 46214930
SMILES: CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C
InChi: InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)
InChi Key: BVAHPPKGOOJSPU-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |