GSK429286A | 2637

GSK429286A is a potent and selective Rho-Kinase (ROCK) inhibitor (IC₅₀ = 14 and 63 nM for ROCK1 and ROCK2, respectively). ROCK inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency.

GSK429286A is a potent and selective Rho-Kinase (ROCK) inhibitor (IC₅₀ = 14 and 63 nM for ROCK1 and ROCK2, respectively). ROCK inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency.

2637 | GSK429286A DataSheet

Alternate Name/Synonyms: 4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide; GSK429286

Appearance: White solid

Formulation: N/A

CAS Number: 864082-47-3

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₆F₄N₄O₂

Molecular Weight: 432.27

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO (~40 mg/ml) or EtOH (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective Rho-kinase (ROCK) inhibitor

MDL Number: MFCD16618404

PubChem CID: 11373846

SMILES: CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F

InChi: nChI=1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-6,8-9,14H,7H2,1H3,(H,26,29)(H,27,30)(H,28,31)

InChi Key: OLIIUAHHAZEXEX-UHFFFAOYSA-N