GSK461364 | 2287

A potent, selective and ATP-competitive inhibitor of Polo Like Kinase 1 (PLK1) (Ki = 2 nM). Displays >100-fold selectivity for PLK1 over PLK2 and PLK3. Shows anti-proliferative activity against several tumor cell lines.

GSK461364 is a potent, selective and ATP-competitive inhibitor of Polo Like Kinase 1 (PLK1) (Ki = 2 nM).

2287 | GSK461364 DataSheet

Alternate Name/Synonyms: 5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-((R)-1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 929095-18-1

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₂₇H₂₈F₃N₅O₂S

Molecular Weight: 543.6

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent polo-like kinase 1 (PLK1) inhibitor

MDL Number: MFCD12755419

PubChem CID: 15983966

SMILES: CC(C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N

InChi: InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31, 36)/t17-/m1/s1

InChi Key: ZHJGWYRLJUCMRT-QGZVFWFLSA-N