26
Guanfacine hydrochloride | B2990
- SKU:
- 26-B2990-GEN
- Availability:
- Usually shipped in 5 working days
Description
Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with anti-hypertensive activity. It shows Ki values of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay. Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner. It also improves spatial working memory deficits induced by hypobaric hypoxia in rats. Guanfacine is used to treat high blood pressure and attention deficit hyperactivity disorder (ADHD).
Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with anti-hypertensive activity. It shows Ki values of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay. Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner. It also improves spatial working memory deficits induced by hypobaric hypoxia in rats. Guanfacine is used to treat high blood pressure and attention deficit hyperactivity disorder (ADHD).
B2990 | Guanfacine hydrochloride DataSheet
Alternate Name/Synonyms: N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide,hydrochloride; N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride; Tenex; N-Amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride; N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide hydrochloride; N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide hydrochloride
Appearance: White powder
Formulation:
CAS Number: 29110-48-3
Structure Available?: True
Peptide sequence:
Salt Form: True
Molecular Formula: C₉H₁₀Cl₃N₃O
Molecular Weight: 282.55
Cell-Permeable?: True
Purity: >98.0%
Solubilities: ~20 mg/ml in DMSO and DMF, ~10 mg/ml in PBS, pH 7.2, ~25 mg/ml in Ethanol
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An α2-adrenergic receptor agonist
MDL Number: MFCD00798230
PubChem CID: 71401
SMILES: C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl
InChi: InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
InChi Key: DGFYECXYGUIODH-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |