Guanfacine hydrochloride | B2990

Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with anti-hypertensive activity. It shows Ki values of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay. Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner. It also improves spatial working memory deficits induced by hypobaric hypoxia in rats. Guanfacine is used to treat high blood pressure and attention deficit hyperactivity disorder (ADHD).

Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with anti-hypertensive activity. It shows Ki values of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay. Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner. It also improves spatial working memory deficits induced by hypobaric hypoxia in rats. Guanfacine is used to treat high blood pressure and attention deficit hyperactivity disorder (ADHD).

B2990 | Guanfacine hydrochloride DataSheet

Alternate Name/Synonyms: N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide,hydrochloride; N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride; Tenex; N-Amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride; N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide hydrochloride; N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide hydrochloride

Appearance: White powder

Formulation:

CAS Number: 29110-48-3

Structure Available?: True

Peptide sequence:

Salt Form: True

Molecular Formula: C₉H₁₀Cl₃N₃O

Molecular Weight: 282.55

Cell-Permeable?: True

Purity: >98.0%

Solubilities: ~20 mg/ml in DMSO and DMF, ~10 mg/ml in PBS, pH 7.2, ~25 mg/ml in Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An α2-adrenergic receptor agonist

MDL Number: MFCD00798230

PubChem CID: 71401

SMILES: C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl

InChi: InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H

InChi Key: DGFYECXYGUIODH-UHFFFAOYSA-N