GW-311616A | B2559

GW-311616 hydrochloride is a potent and selective intracellular neutrophil elastase (NE, α-1-proteinase) inhibitor. Inhibits human neutrophil elastase (HNE) and is selective over other human serine proteases with IC₅₀ values of 22 nM for HNE, >100 μM for trypsin, cathepsin G and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator.

GW-311616 hydrochloride is a potent and selective intracellular neutrophil elastase (NE, α-1-proteinase) inhibitor. Inhibits human neutrophil elastase (HNE) and is selective over other human serine proteases with IC₅₀ values of 22 nM for HNE, >100 μM for trypsin, cathepsin G and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator.=]

B2559 | GW-311616A DataSheet

Alternate Name/Synonyms: (3S,3aS,6aR)-3-Isopropyl-1-(methylsulfonyl)-4-((E)-4-(piperidin-1-yl)but-2-enoyl) hexahydropyrrolo [3,2-b]pyrrol-2(1H)-one hydrochloride, GW311616 hydrochloride

Appearance: Crystalline solid

Formulation:

CAS Number: 197890-44-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₃₁N₃O₄S . HCl

Molecular Weight: 434.0

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: in DMSO, in Water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent, selective intracellular neutrophil elastase (NE, α-1-proteinase) inhibitor

MDL Number:

PubChem CID: 9889108

SMILES: CC(C)C1C2C(CCN2C(=O)C=CCN3CCCCC3)N(C1=O)S(=O)(=O)C.Cl

InChi: InChI=1S/C19H31N3O4S.ClH/c1-14(2)17-18-15(22(19(17)24)27(3,25)26)9-13-21(18)16(23)8-7-12-20-10-5-4-6-11-20;/h7-8,14-15,17-18H,4-6,9-13H2,1-3H3;1H/b8-7+;/t15-,17+,18-;/m1./s1

InChi Key: UFCZUKYPBPXODT-OFTZGUNKSA-N