Description
GW-311616 hydrochloride is a potent and selective intracellular neutrophil elastase (NE, α-1-proteinase) inhibitor. Inhibits human neutrophil elastase (HNE) and is selective over other human serine proteases with IC₅₀ values of 22 nM for HNE, >100 μM for trypsin, cathepsin G and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator.
GW-311616 hydrochloride is a potent and selective intracellular neutrophil elastase (NE, α-1-proteinase) inhibitor. Inhibits human neutrophil elastase (HNE) and is selective over other human serine proteases with IC₅₀ values of 22 nM for HNE, >100 μM for trypsin, cathepsin G and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator.=]
Alternate Name/Synonyms: (3S,3aS,6aR)-3-Isopropyl-1-(methylsulfonyl)-4-((E)-4-(piperidin-1-yl)but-2-enoyl) hexahydropyrrolo [3,2-b]pyrrol-2(1H)-one hydrochloride, GW311616 hydrochloride
Appearance: Crystalline solid
Formulation:
CAS Number: 197890-44-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₃₁N₃O₄S . HCl
Molecular Weight: 434.0
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: in DMSO, in Water
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent, selective intracellular neutrophil elastase (NE, α-1-proteinase) inhibitor
MDL Number:
PubChem CID: 9889108
SMILES: CC(C)C1C2C(CCN2C(=O)C=CCN3CCCCC3)N(C1=O)S(=O)(=O)C.Cl
InChi: InChI=1S/C19H31N3O4S.ClH/c1-14(2)17-18-15(22(19(17)24)27(3,25)26)9-13-21(18)16(23)8-7-12-20-10-5-4-6-11-20;/h7-8,14-15,17-18H,4-6,9-13H2,1-3H3;1H/b8-7+;/t15-,17+,18-;/m1./s1
InChi Key: UFCZUKYPBPXODT-OFTZGUNKSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
