GW-3965 hydrochloride | 9402

GW-3965 hydrochloride is a non-steroidal liver X receptor agonist on hLXRα and hLXRβ. GW3965 has an EC₅₀ = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC₅₀ = 190 nM and 30 nM, respectively. Up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.

GW-3965 hydrochloride is a non-steroidal liver X receptor agonist on hLXRα and hLXRβ. GW3965 has an EC₅₀ = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC₅₀ = 190 nM and 30 nM, respectively.

9402 | GW-3965 hydrochloride DataSheet

Alternate Name/Synonyms: 2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic Acid hydrochloride

Appearance: White solid

Formulation: N/A

CAS Number: 405911-17-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₃H₃₁ClF₃NO₃.HCl

Molecular Weight: 618.51

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A non-steroidal liver X receptor agonist on hLXRα and hLXRβ

MDL Number: N/A

PubChem CID: 16078973

SMILES: C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl

InChi: InChI=1S/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26;/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40);1H

InChi Key: NMPUWJFHNOUNQU-UHFFFAOYSA-N