GW-441756 | B1147

GW-441756 is potent and specific inhibitor of Trk A (tropomyosin-related kinase A) tyrosine kinase (IC₅₀ = 2 nM). This inhibition of TrkA reduces cell proliferation and enhances the effects of chemotherapeutic agents in sarcoma. GW-441756 displays >100-fold selectivity over a range of other kinases.

GW-441756 is potent and specific inhibitor of Trk A (tropomyosin-related kinase A) tyrosine kinase (IC₅₀ = 2 nM). This inhibition of TrkA reduces cell proliferation and enhances the effects of chemotherapeutic agents in sarcoma. GW-441756 displays >100-fold selectivity over a range of other kinases.

B1147 | GW-441756 DataSheet

Alternate Name/Synonyms: 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one

Appearance: Red Solid

Formulation: N/A

CAS Number: 504433-23-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₃N₃O

Molecular Weight: 275.31

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~4 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and specific inhibitor of Trk A

MDL Number:

PubChem CID: 9943465

SMILES: CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC=N4)NC3=O

InChi: 1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9-

InChi Key: NXNQLECPAXXYTR-LCYFTJDESA-N