GW-6471 | 9453

GW-6471 is a potent PPARα antagonist (IC₅₀ = 240 nM). It drives the displacement of coactivators from PPARα and promotes the recruitment of co-repressor proteins like nuclear co-repressor. GW-6471 significantly prevents cardiomyocyte differentiation and results in the reduced expression of cardiac sarcomeric proteins and specific genes in a time-dependent manner.

GW-6471 is a potent PPARα antagonist (IC₅₀ = 240 nM). It drives the displacement of coactivators from PPARα and promotes the recruitment of co-repressor proteins like nuclear co-repressor. GW-6471 significantly prevents cardiomyocyte differentiation and results in the reduced expression of cardiac sarcomeric proteins and specific genes in a time-dependent manner.

9453 | GW-6471 DataSheet

Alternate Name/Synonyms: N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide

Appearance: Cream-colored solid

Formulation: N/A

CAS Number: 880635-03-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₃₅H₃₆F₃N₃O₄

Molecular Weight: 619.67

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (~40 mg/ml) or EtOH (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent PPARα antagonist

MDL Number: N/A

PubChem CID: 446738

SMILES: CCC(=O)NCC(CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)NC(=CC(=O)C4=CC=C(C=C4)C(F)(F)F)C

InChi: InChI=1S/C35H36F3N3O4/c1-4-33(43)39-22-29(40-23(2)20-32(42)26-12-14-28(15-13-26)35(36,37)38)21-25-10-16-30(17-11-25)44-19-18-31-24(3)45-34(41-31)27-8-6-5-7-9-27/h5-17,20,29,40H,4,18-19,21-22H2,1-3H3,(H,39,43)/b23-20-/t29-/m0/s1

InChi Key: TYEFSRMOUXWTDN-DYQICHDWSA-N