GW 9508 | 2817

GW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) with pEC₅₀ of 7.32; 100-fold selective against GPR120. Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC₅₀ = 6.14).

GW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) with pEC₅₀ of 7.32; 100-fold selective against GPR120. Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC₅₀ = 6.14).

2817 | GW 9508 DataSheet

Alternate Name/Synonyms: 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid

Appearance: Beige solid

Formulation: N/A

CAS Number: 885101-89-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₁NO₃

Molecular Weight: 347.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~30 mg/ml) or EtOH (~ 30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective agonist for the free fatty acid receptor FFA1 (GPR40)

MDL Number: MFCD09753282

PubChem CID: 11595431

SMILES: C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O

InChi: InChI=1S/C22H21NO3/c24-22(25)14-11-17-9-12-19(13-10-17)23-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15,23H,11,14,16H2,(H,24,25)

InChi Key: DGENZVKCTGIDRZ-UHFFFAOYSA-N