GW501516 | 1971

A selective agonist for PPARδ (peroxisome proliferator-activated receptorδ) (EC₅₀ = 1. 1 nM), displaying 1000-fold selectivity over the other human subtypes. In macrophages, fibroblasts, and intestinal cells, GW501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux.

GW501516 is a selective agonist for PPARδ (peroxisome proliferator-activated receptorδ) (EC₅₀ = 1. 1 nM), displaying 1000-fold selectivity over the other human subtypes. In macrophages, fibroblasts, and intestinal cells, GW501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux.

1971 | GW501516 DataSheet

Alternate Name/Synonyms: (2-Methyl-4-(((4-methyl-2-(4-trifluoromethylphenyl)-1,3-thiazol-5-yl)methyl)sulfanyl)phenoxy)acetic acid

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 317318-70-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₈F₃NO₃S₂

Molecular Weight: 453.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (50 mg/ml) or EtOH (12 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A selective agonist for PPARδ

MDL Number: MFCD09033000

PubChem CID: 9803963

SMILES: CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O

InChi: InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13 (2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26, 27)

InChi Key: YDBLKRPLXZNVNB-UHFFFAOYSA-N