Description
GW788388 is a potent and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5) (IC₅₀ = 18 nM). Also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.
GW788388 is a potent and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5) (IC₅₀ = 18 nM). Also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.
Alternate Name/Synonyms: 4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-benzamide
Appearance: Off-white solid
Formulation: N/A
CAS Number: 452342-67-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₂₃N₅O₂
Molecular Weight: 425.48
Cell-Permeable?: yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective transforming growth factor beta receptor I (TGF-βR1) inhibitor
MDL Number: MFCD20527321
PubChem CID: 10202642
SMILES: C1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5
InChi: InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31)
InChi Key: SAGZIBJAQGBRQA-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |