GZD824 | 2795

GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC₅₀ of 0.34 nM and 0.68 nM, respectively.

GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC₅₀ of 0.34 nM and 0.68 nM, respectively.

2795 | GZD824 DataSheet

Alternate Name/Synonyms: 4-Methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide

Appearance: White solid

Formulation: N/A

CAS Number: 1257628-77-5

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₂₇F₃N₆O

Molecular Weight: 532.56

Cell-Permeable?: Y

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An orally bioavailable Bcr-Abl inhibitor

MDL Number: N/A

PubChem CID: 51038269

SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CC5=C(NN=C5)N=C4

InChi: InChI=1S/C29H27F3N6O/c1-19-3-5-22(14-21(19)6-4-20-13-24-17-34-36-27(24)33-16-20)28(39)35-25-8-7-23(26(15-25)29(30,31)32)18-38-11-9-37(2)10-12-38/h3,5,7-8,13-17H,9-12,18H2,1-2H3,(H,35,39)(H,33,34,36)

InChi Key: TZKBVRDEOITLRB-UHFFFAOYSA-N