H-Cadherin polyclonal Antibody | BS90614

H-Cadherin polyclonal Antibody | BS90614 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: IHC WB

Application Range: IHC:1:50-1:200 WB:1:50-1:200

Background: Cadherins comprise a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogen-esis. Cadherins each contain a large extracellular domains characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function. T-cadherin (for truncated-cadherin), also designated heart-cadherin or cadherin-13) expression levels have been shown to be reduced in human breast cancers and carcinoma cell lines. Evidence suggests that decreased levels of T-cadherin indicate a progression in breast malignancies.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: H-Cadherin polyclonal Antibody detects endogenous levels of H-Cadherin protein.

Molecular Weight: 78 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: H-cadherin, T-cad, T-cadherin, CDH13, CDHH, CAD13, Cadherin-13, CDH13, CDHH, H-cadherin, Heart cadherin, P105, T cad, T Cadherin, T-cad, T-cadherin, Truncated cadherin,

Immunogen: Recombinant protein within human H Cadherin aa 1-200.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: