H3f3b Antibody (Center) [APR33365G]

H3f3b Antibody (Center) [APR33365G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This H3f3b antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 31-65 amino acids from human H3f3b.

Cellular Localisation: Nucleus. Chromosome.

Molecular Weight: 15328

Clone: Polyclonal

Gene Name: H3-3a {ECO:0000250|UniProtKB:P84243}

Gene ID: 15078;15081

Function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Histone H33, H3f3a, H33a