HA 130 | B1192

HA 130 is a potent and eversible inhibitor of autotaxin (ATX) (IC₅₀ = 28 nM). It does not affect the activity of any proteasomal protease or related enzymes. HA-130 rapidly decreases plasma lysophosphatidic acid levels in mice when given intravenously (1 nM/g).

HA 130 is a potent and eversible inhibitor of autotaxin (ATX) (IC₅₀ = 28 nM). It does not affect the activity of any proteasomal protease or related enzymes. HA-130 rapidly decreases plasma lysophosphatidic acid levels in mice when given intravenously (1 nM/g).

B1192 | HA 130 DataSheet

Alternate Name/Synonyms: B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid

Appearance: White Solid

Formulation: N/A

CAS Number: 1229652-21-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₁₉BFNO₅S

Molecular Weight: 463.29

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>45 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and reversible inhibitor of autotaxin (ATX)

MDL Number:

PubChem CID: 46911532

SMILES: B(C1=CC=C(C=C1)COC2=CC=C(C=C2)C=C3C(=O)N(C(=O)S3)CC4=CC=C(C=C4)F)(O)O

InChi: 1S/C24H19BFNO5S/c26-20-9-3-17(4-10-20)14-27-23(28)22(33-24(27)29)13-16-5-11-21(12-6-16)32-15-18-1-7-19(8-2-18)25(30)31/h1-13,30-31H,14-15H2/b22-13-

InChi Key: VTNKMYWFWQTEHE-XKZIYDEJSA-N