HAND1 Antibody (N-term) [AMM08775G]

HAND1 Antibody (N-term) [AMM08775G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: Rat

Specificity: This HAND1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 83-116 amino acids from the N-terminal region of human HAND1.

Cellular Localisation: Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity) .

Molecular Weight: 23627

Clone: Polyclonal

Gene Name: HAND1

Gene ID: 9421

Function: Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity) . Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity) . Acts as a transcriptional repressor of SOX15 (By similarity) . In the adult, could be required for ongoing expression of cardiac-specific genes (PubMed:9931445) .

Summary: Tissue Location: Heart.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Heart- and neural crest derivatives-expressed protein 1, Class A basic helix-loop-helix protein 27, bHLHa27, Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1, eHAND, HAND1, BHLHA27, EHAND