Haptoglobin, Human Plasma (Mixed Type) | 7535

An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype.

7535 | Haptoglobin Human Plasma Mixed Type DataSheet

Biomolecule/Target: Haptoglobin

Synonyms: Haptoglobin b-Chain, haptoglobin a-chain; Hp; Bp

Alternates names: Haptoglobin b-Chain, haptoglobin a-chain; Hp; Bp

Taglines: An acute-phase plasma protein, which binds hemoglobin and prevents loss of iron through the kidneys

NCBI Gene ID #: 6376

NCBI Gene Symbol: CX3CL1

Gene Source: Human

Accession #: P78423

Recombinant: No

Source: Human Plasma

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: Hp 1-1: 86 kDa; Hp 2-1: 200 kDa; Hp 2-2: 400 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized as a salt-free solid.

Reconstitution Instructions: N/A

Amino acid sequence: N/A