Harmine | 2561

Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC₅₀’s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 µM; DYRK4 = 80 µM). Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells(GSLC’s) possibly via inhibition of Akt phosphorylation. Selective competitive and reversible inhibitor of MAO-A (IC₅₀ = 8 µM). Also regulates PPARγ expression and displays antidiabetic activity.

Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC₅₀’s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 µM; DYRK4 = 80 µM). Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells(GSLC’s) possibly via inhibition of Akt phosphorylation.

2561 | Harmine DataSheet

Alternate Name/Synonyms: 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 442-51-3

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₂N₂O

Molecular Weight: 212.25

Cell-Permeable?: Yes

Purity: ≥98% by titration

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A MAO-A and DYRK inhibitor

MDL Number: MFCD00004958

PubChem CID: 5280953

SMILES: CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC

InChi: InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3

InChi Key: BXNJHAXVSOCGBA-UHFFFAOYSA-N