HAX1 Antibody (C-term) [AMM05300G]

HAX1 Antibody (C-term) [AMM05300G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This HAX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the C-terminal region of human HAX1.

Cellular Localisation: Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O35387}. Cytoplasm, cell cortex. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q7TSE9}. Cytoplasm, P-body [Isoform 3]: Cytoplasm. Nucleus Note=Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro) . [Isoform 5]: Cytoplasm. Note=Predominantly cytoplasmic

Molecular Weight: 31621

Clone: Polyclonal

Gene Name: HAX1

Gene ID: 10456

Function: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484) . Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484) . Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

Summary: Tissue Location: Ubiquitous. Up-regulated in oral cancers.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: HCLS1-associated protein X-1, HS1-associating protein X-1, HAX-1, HS1-binding protein 1, HSP1BP-1, HAX1, HS1BP1