HBX-41108 | 9608

HBX-41108 is a potent inhibitor of ubiquitin-specific protease (USP) 7 activity (IC₅₀ = 424 nM). Also inhibits USP7-mediated p53 deubiquitination (IC₅₀ = 0.8 μM). HBX-41108 treatment stabilizes p53, activates the transcription of a p53 target gene without inducing genotoxic stress, and inhibits cancer cell growth. Also induces p53-dependent apoptosis in p53 wild type and isogenic cancer cell lines.

HBX-41108 is a potent inhibitor of ubiquitin-specific protease (USP) 7 activity (IC₅₀ = 424 nM). Also inhibits USP7-mediated p53 deubiquitination (IC₅₀ = 0.8 μM). HBX-41108 treatment stabilizes p53, activates the transcription of a p53 target gene without inducing genotoxic stress, and inhibits cancer cell growth. Also induces p53-dependent apoptosis in p53 wild type and isogenic cancer cell lines.

9608 | HBX-41108 DataSheet

Alternate Name/Synonyms: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

Appearance: Yellow solid

Formulation: N/A

CAS Number: 924296-39-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₃ClN₄O

Molecular Weight: 266.64

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of ubiquitin-specific protease (USP) 7 activity

MDL Number: N/A

PubChem CID: 16065773

SMILES: C1=CC2=C(C=C1Cl)C(=O)C3=NC(=C(N=C23)C#N)C#N

InChi: InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H

InChi Key: BIGPXXAUSQLTQR-UHFFFAOYSA-N