HDAC1 Monoclonal Antibody | E-AB-22208

HDAC1 Monoclonal Antibody | E-AB-22208 | Gentaur UK, US & Europe Distribution

Type: Monoclonal Antibody

Synonyms: DKFZp686H12203, GON 10, HD1, HDAC 1, HDAC1, HDAC1, Histone deacetylase 1, Reduced potassium dependency yeast homolog like 1, RPD3, RPD3L1

Application: IHC-p

Reactivity: Human, Mouse, Rat

Host: Mouse

Isotype: IgG

Reserch Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Stem Cells

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic Peptide of HDAC1

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification Method: Protein A purification

Dilution: IHC 1:100-200

Clone: Clone:4E1

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A