HDAC10 Antibody (N-term) [APR14329G]

HDAC10 Antibody (N-term) [APR14329G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This HDAC10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human HDAC10.

Cellular Localisation: Cytoplasm. Nucleus Note=Excluded from nucleoli.

Molecular Weight: 71445

Clone: Polyclonal

Gene Name: HDAC10

Gene ID: 83933

Function: Polyamine deacetylase (PDAC), which acts preferentially on N (8) -acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954) . Exhibits attenuated catalytic activity toward N (1), N (8) -diacetylspermidine and very low activity, if any, toward N (1) -acetylspermidine (PubMed:28516954) . Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383) . Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039) . The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954) . May play a role in the promotion of late stages of autophagy, possibly autophagosome- lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769) . May play a role in homologous recombination (PubMed:21247901) . May promote DNA mismatch repair (PubMed:26221039) .

Summary: Tissue Location: Widely expressed with high levels in liver and kidney.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Histone deacetylase 10, HD10, HDAC10