HDAC6 Antibody| F41165-0.08ML/F41165-0.4ML/F54055-0.1ML/R30680

HDAC6 Antibody| F41165-0.08ML/F41165-0.4ML/F54055-0.1ML/R30680 | Gentaur UK, US & Europe Distribution

Background: HDAC6 (histone deacetylase 6) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays a central role in microtubule-dependent cell motility via deacetylation of tubulin, and has been shown to interact with HDAC11, SIRT2, and F-actin. HDAC6 is ubiquitinated, but its polyubiquitination however does not lead to degradation. HDAC is also a potential target of sumoylation.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human, Mouse

Predicted Spacies Reactivity: N/A

Application: IHC, WB, ELISA

Application Details: IHC (Paraffin): 1:10-1:50, Western blot: 1:1000

Application Note: Titration of the HDAC6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This HDAC6 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 1182-1215 from the human protein was used as the immunogen for this HDAC6 antibody.

Storage: Aliquot the HDAC6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A