HDM-201 | B2459

Siremadlin (NVP-HDM201) is a potent and highly specific MDM-2/p53 inhibitor. It binds to human MDM2 protein with a picomolar Ki value (0.21 nM). It activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells.

Siremadlin (NVP-HDM201) is a potent and highly specific MDM-2/p53 inhibitor. It binds to human MDM2 protein with a picomolar Ki value (0.21 nM). It activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells.

B2459 | HDM-201 DataSheet

Alternate Name/Synonyms: Siremadlin; NVP-HDM 201; (S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl) -1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one

Appearance: Crystalline solid

Formulation:

CAS Number: 1448867-41-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₄Cl₂N6O₄

Molecular Weight: 555.41

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A highly potent p53-MDM2 interaction inhibitor

MDL Number:

PubChem CID: 71678098

SMILES: CC(C)N1C2=C(C(=O)N(C2C3=CC=C(C=C3)Cl)C4=CC(=CN(C4=O)C)Cl)N=C1C5=CN=C(N=C5OC)OC

InChi: InChI=1S/C26H24Cl2N6O4/c1-13(2)33-21-19(30-22(33)17-11-29-26(38-5)31-23(17)37-4)25(36)34(18-10-16(28)12-32(3)24(18)35)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3/t20-/m0/s1

InChi Key: AGBSXNCBIWWLHD-FQEVSTJZSA-N