Heptelidic Acid | 2215

A sesquiterpene antibiotic, isolated from Trichoderma sp. A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation. Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols.

Heptelidic acid is a potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation.

2215 | Heptelidic Acid DataSheet

Alternate Name/Synonyms: Koningic acid; Avocettin; FO-4443; BRN 5091359

Appearance: White solid

Formulation: N/A

CAS Number: 74310-84-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₂₀O₅

Molecular Weight: 280.32

Cell-Permeable?: Yes

Purity: ³95% by HPLC

Solubilities: DMSO or EtOH

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor

MDL Number: N/A

PubChem CID: 124361

SMILES: CC(C)C1CCC2(CO2)C3C1C=C(COC3=O)C(=O)O

InChi: InChI=1S/C15H20O5/c1-8(2)10-3-4-15(7-20-15)12-11(10)5-9(13(16)17)6-19-14(12)18/h5,8,10-12H,3-4,6-7H2,1-2H3,(H,16,17)/t10?,11-,12-,15-/m1/s1

InChi Key: JESMSCGUTIEROV-NOFREYILSA-N