Heregulin-2 (HRG2), Human Recombinant | 4730

Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG-2 is a signaling protein for ErbB2/ErbB4 receptor on the cardiac muscle cells. The polypeptide is comprised of an immunoglobulin and epidermal growth factor-like (EGF-like) domains.

4730 | Heregulin-2 HRG2 Human Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Heregulin-2 (HRG2), Human Recombinant

Alternates names: Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein

Taglines: A signaling protein for ErbB2/ErbB4 receptor

NCBI Gene ID #: 3486

NCBI Gene Symbol: IBP3

Gene Source: Human

Accession #: P17936

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: 95%

Assay #2: HPLC

Endotoxin Level: <0.1 ng per µg of Heregulin-1

Activity (Specifications/test method): N/A

Biological activity: The ED as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is <0.2 mg/ml, in the presence of 15 ng/ml of human IGF-II.

Results: <0.2 mg/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 28.8 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized from water.

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A