Description
Hesperadin is a potent, ATP-competitive inhibitor of Aurora B kinase (IC₅₀ = 250 nM). Hesperadin inhibits Aurora B kinase by phosphorylation of histone H3. Also acts as a broad-spectrum influenza antiviral agent.
Hesperadin is a potent, ATP-competitive inhibitor of Aurora B kinase (IC₅₀ = 250 nM). Hesperadin inhibits Aurora B kinase by phosphorylation of histone H3. Also acts as a broad-spectrum influenza antiviral agent.
Alternate Name/Synonyms: N-[(3Z)-2-oxo-3-[phenyl-[4-(piperidin-1-ylmethyl)anilino]methylidene]-1H-indol-5-yl]ethanesulfonamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 422513-13-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₉H₃₂N₄O₃S
Molecular Weight: 516.65
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>25 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, ATP-competitive inhibitor of Aurora B kinase
MDL Number: N/A
PubChem CID: 10142586
SMILES: CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=O)C2=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN5CCCCC5
InChi: InChI=1S/C29H32N4O3S/c1-2-37(35,36)32-24-15-16-26-25(19-24)27(29(34)31-26)28(22-9-5-3-6-10-22)30-23-13-11-21(12-14-23)20-33-17-7-4-8-18-33/h3,5-6,9-16,19,30,32H,2,4,7-8,17-18,20H2,1H3,(H,31,34)/b28-27-
InChi Key: GLDSKRNGVVYJAB-DQSJHHFOSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |