Hesperadin | B1940

Hesperadin is a potent, ATP-competitive inhibitor of Aurora B kinase (IC₅₀ = 250 nM). Hesperadin inhibits Aurora B kinase by phosphorylation of histone H3. Also acts as a broad-spectrum influenza antiviral agent.

Hesperadin is a potent, ATP-competitive inhibitor of Aurora B kinase (IC₅₀ = 250 nM). Hesperadin inhibits Aurora B kinase by phosphorylation of histone H3. Also acts as a broad-spectrum influenza antiviral agent.

B1940 | Hesperadin DataSheet

Alternate Name/Synonyms: N-[(3Z)-2-oxo-3-[phenyl-[4-(piperidin-1-ylmethyl)anilino]methylidene]-1H-indol-5-yl]ethanesulfonamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 422513-13-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₃₂N₄O₃S

Molecular Weight: 516.65

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, ATP-competitive inhibitor of Aurora B kinase

MDL Number: N/A

PubChem CID: 10142586

SMILES: CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=O)C2=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN5CCCCC5

InChi: InChI=1S/C29H32N4O3S/c1-2-37(35,36)32-24-15-16-26-25(19-24)27(29(34)31-26)28(22-9-5-3-6-10-22)30-23-13-11-21(12-14-23)20-33-17-7-4-8-18-33/h3,5-6,9-16,19,30,32H,2,4,7-8,17-18,20H2,1H3,(H,31,34)/b28-27-

InChi Key: GLDSKRNGVVYJAB-DQSJHHFOSA-N