LBD
HEXB Antibody (Center) [AMM05335G]
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- LBD-AMM05335G
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Description
HEXB Antibody (Center) [AMM05335G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This HEXB antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 170-203 amino acids from the Central region of human HEXB.
Cellular Localisation: Lysosome. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:P20060}
Molecular Weight: 63111
Clone: Polyclonal
Gene Name: HEXB (HGNC:4879)
Gene ID: 3074
Function: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:9694901, PubMed:8672428, PubMed:8123671) . The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436) . Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:9694901, PubMed:8672428, PubMed:8123671) . During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity) .
Summary: N/A
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Beta-hexosaminidase subunit beta, 3.2.1.52, Beta-N-acetylhexosaminidase subunit beta, Hexosaminidase subunit B, Cervical cancer proto-oncogene 7 protein, HCC-7, N-acetyl-beta-glucosaminidase subunit beta, Beta-hexosaminidase subunit beta chain B, Beta-hexosaminidase subunit beta chain A, HEXB