Histone H4 (Tri-Methyl K20) polyclonal Antibody | BS7676

Histone H4 (Tri-Methyl K20) polyclonal Antibody | BS7676 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Other (Wide Range)

Application: WB,IHC,IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Histone H4 (Tri-Methyl K20) polyclonal Antibody detects endogenous levels of histone H4 only when Tri-methylated at Lys20.

Molecular Weight: ~11 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Histone H4K20me3

Immunogen: Synthetic peptide conjugated to KLH derived from within residues 1-100 of Human Histone H4, Tri methylated at K20.

Conjugate: Unconjugated

Modification: Methylated

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: