HN1 Antibody (Center) [APR04016G]

HN1 Antibody (Center) [APR04016G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This HN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human HN1.

Cellular Localisation: Nucleus. Cytoplasm

Molecular Weight: 16015

Clone: Polyclonal

Gene Name: JPT1 (HGNC:14569)

Gene ID: 51155

Function: Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408) . Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422) . Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365) . Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408) .

Summary: Tissue Location: Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IF, FC

Dilution: WB--1:1000 IF--1:10~50 FC--1:10~50

Synonyms: Hematological and neurological expressed 1 protein, Androgen-regulated protein 2, Hematological and neurological expressed 1 protein, N-terminally processed, HN1, ARM2