HP Antibody (Center) [APR30660G]

HP Antibody (Center) [APR30660G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This HP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-322 amino acids from the Central region of human HP.

Cellular Localisation: Secreted.

Molecular Weight: 45205

Clone: Polyclonal

Gene Name: HP

Gene ID: 3240

Function: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.

Summary: Tissue Location: Expressed by the liver and secreted in plasma.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P-Leica, FC, IF, WB

Dilution: IHC-P-Leica--1:500 WB--1:2000 WB--1:1000 WB--1:1000-1:2000 IHC-P--1:100~500 FC--1:10~50 IF--1:10~50

Synonyms: Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain, HP