HPN Antibody (Center) [ApR04812G]

HPN Antibody (Center) [ApR04812G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This HPN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 153-188 amino acids from the Central region of human HPN.

Cellular Localisation: Cell membrane; Single-pass type II membrane protein Apical cell membrane; Single-pass type II membrane protein

Molecular Weight: 45011

Clone: Polyclonal

Gene Name: HPN

Gene ID: 3249

Function: Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837) . Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933) . Plays a role in the proteolytic processing of ACE2 (PubMed:24227843) . Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890) .

Summary: Tissue Location: Detected in liver and kidney.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Serine protease hepsin, Transmembrane protease serine 1, Serine protease hepsin non-catalytic chain, Serine protease hepsin catalytic chain, HPN, TMPRSS1