HPSE polyclonal Antibody | BS7817

HPSE polyclonal Antibody | BS7817 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IF

Application Range: WB: 1:500~1:2000 IF: 1:50~1:200

Background: Heparanases (HPA) degrade heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix and play animportant role in the extravasation of blood-borne tumor cells and inflammatory leukocytes. HPA1 dismantles the subendothelial basal membrane and facilitates the metastasis of blood-borne tumor cells. Furthermore, HPA1 induces angiogenesis and likely promotes the vascularization of tumors. Upon degradation, HPAs free growth factors and cytokines that stimulate cell proliferation and chemotaxis. Fibroblasts endocytose extracellular HPA1 for cytoplasmic accumulation in vitro. Proteolytic processing at the cell surface of a precursor begets an active form of HPA1.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HPSE polyclonal Antibody detects endogenous levels of HPSE protein.

Molecular Weight: ~ 50, 65 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Endo glucoronidase; Endo-glucoronidase; HEP; Heparanase 50 kDa subunit; Heparanase; Heparanase-1; Heparanase1; Hpa 1; HPA; Hpa1; HPR 1; HPR1; HPSE 1; HPSE; HPSE_HUMAN; HPSE1; HSE 1; HSE1;

Immunogen: Recombinant full length Human HPSE.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: