HRSP12 polyclonal Antibody | BS70623

HRSP12 polyclonal Antibody | BS70623 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: HRSP12 (heat-responsive protein 12), also known as PSP, P14.5 or UK114, is a 137 amino acid protein that belongs to the UPF0076 (UK114) family and is expressed primarily in liver and kidney. Localized to the cytoplasm in highly differentiated cells and to the nucleus in less differentiated cells, HRSP12 functions as an endoribonuclease that inhibits translation by cleaving mRNA. Specifically, HRSP12 cleaves phosphodiester bonds in single-stranded mRNA, thereby breaking the mRNA and preventing protein synthesis. HRSP12 exists as a homotrimer and may be a tumor antigen involved in malignant neoplasms. This suggests a possible role in carcinogenesis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HRSP12 polyclonal Antibody detects endogenous levels of HRSP12 protein.

Molecular Weight: ~ 14.5 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Ribonuclease UK114; p14.5; Heat-responsive protein 12; UK114 antigen homolog; PSP

Immunogen: Recombinant protein of human HRSP12.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: