HS-1371 | B2430

HS-1371 is a potent RIP3 kinase inhibitor (IC₅₀ = 20.8 nM). It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro. . It inhibits TNF-induced necroptosis but does not inhibit TNF-induced apoptosis, indicating that HS-1371 has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity.

HS-1371 is a potent RIP3 kinase inhibitor (IC₅₀ = 20.8 nM). It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro.

B2430 | HS-1371 DataSheet

Alternate Name/Synonyms: 4-(4-methylphenoxy)-7-(1-piperidin-4-ylpyrazol-4-yl)quinoline, EX-A2073, HS1371

Appearance: Crystalline solid

Formulation:

CAS Number: 2158197-70-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₄N₂₄O

Molecular Weight: 384.47

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >10 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent RIP3 kinase inhibitor

MDL Number:

PubChem CID: 134817449

SMILES: CC1=CC=C(C=C1)OC2=C3C=CC(=CC3=NC=C2)C4=CN(N=C4)C5CCNCC5

InChi: InChI=1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3

InChi Key: VPVLPCIBKVWFDT-UHFFFAOYSA-N